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1.
Impact of Innate Immunity, Endothelial Damage, and Metabolic Biomarkers on COVID-19 Severity and Mortality.
Rocco, Joseph M; Laghetti, Paola; Di Stefano, Mariantonietta; Sereti, Irini; Ortega-Villa, Ana; Wang, Jing; Rupert, Adam; Chironna, Maria; Ye, Lara; Liu, Xiangdong; Anderson, Megan V; Burbelo, Peter B; Fiore, Jose Ramon; Saracino, Annalisa; Lisco, Andrea.
Open Forum Infect Dis ; 9(9): ofac427, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-2212860

ABSTRACT

In this study, abnormal levels of myeloid activation, endothelial damage, and innate immune markers were associated with severe coronavirus disease 2019 (COVID-19), while higher levels of metabolic biomarkers (irisin, leptin) demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically predisposed individuals.

2.
Impact of innate immunity, endothelial damage, and metabolic biomarkers on COVID-19 severity and mortality
Rocco, Joseph M.; Laghetti, Paola, Di Stefano, Mariantonietta, Sereti, Irini, Ortega-Villa, Ana, Wang, Jing, Rupert, Adam, Chironna, Maria, Ye, Peiying, Liu, Xiangdong, Anderson, Megan V.; Burbelo, Peter B.; Fiore, Jose Ramon, Saracino, Annalisa, Lisco, Andrea.
Open forum infectious diseases ; 2022.
Article in English | EuropePMC | ID: covidwho-2012411

ABSTRACT

In this study, abnormal levels of myeloid activation, endothelial damage and innate immune markers were associated with severe COVID-19, while higher levels of metabolic biomarkers (irisin, leptin), demonstrated a protective effect. These data support a model for COVID-19 immunopathogenesis linking robust inflammation and endothelial damage in metabolically-predisposed individuals.

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